Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection.
| Publication Type | Academic Article |
| Authors | Poston D, Weisblum Y, Wise H, Templeton K, Jenks S, Hatziioannou T, Bieniasz P |
| Journal | Clin Infect Dis |
| Volume | 73 |
| Issue | 5 |
| Pagination | e1208-e1211 |
| Date Published | 09/07/2021 |
| ISSN | 1537-6591 |
| Abstract | Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable. |
| DOI | 10.1093/cid/ciaa1803 |
| PubMed ID | 33270134 |
| PubMed Central ID | PMC7799301 |