Beyond the growth curve: CBASS stops phages without killing.
| Publication Type | Comment |
| Authors | Monge M, Aviram N |
| Journal | Cell Host Microbe |
| Volume | 34 |
| Issue | 8 |
| Pagination | 1581-1583 |
| Date Published | 08/12/2026 |
| ISSN | 1934-6069 |
| Keywords | Bacteriophages, Bacterial Proteins |
| Abstract | Bacterial anti-phage systems are often assumed to sacrifice infected cells, particularly when studied through population-level assays or effector overexpression. Huiting et al. show that a membrane-associated CBASS effector, examined at native expression levels, blocks phage production while preserving host-cell viability, challenging how immune outcomes are defined across bacterial defense systems. |
| DOI | 10.1016/j.chom.2026.06.020 |
| PubMed ID | 42586041 |