An EBV+ lymphoepithelioma-like cholangiocarcinoma in a young woman with chronic hepatitis B.
| Publication Type | Case Report |
| Authors | Gearty S, Al Jurdi A, Pittman M, Gupta R |
| Journal | BMJ Case Rep |
| Volume | 12 |
| Issue | 7 |
| Date Published | 07/08/2019 |
| ISSN | 1757-790X |
| Keywords | Carcinoma, Cholangiocarcinoma, Epstein-Barr Virus Infections |
| Abstract | Epstein-Barr virus (EBV) is implicated in the tumorigenesis of a variety of malignancies, including Burkitt's lymphoma, Hodgkin's disease and nasopharyngeal carcinoma (NPC). EBV+ lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare type of intrahepatic cholangiocarcinoma with a distinct pathology and poorly understood treatment options. Morphologically, this neoplasm resembles undifferentiated NPC, a commonly EBV+ tumour with a prominent lymphoid infiltrate. Almost all of the current literature regarding LELCC describes early stage tumours that are treated surgically and achieve good outcomes. In contrast, this report documents a late stage LELCC treated unsuccessfully with systemic chemotherapy. |
| DOI | 10.1136/bcr-2019-229520 |
| PubMed ID | 31289161 |
| PubMed Central ID | PMC6615824 |