Human FcγRIIIa activation on splenic macrophages drives dengue pathogenesis in mice.
| Publication Type | Academic Article |
| Authors | Yamin R, Kao K, MacDonald M, Cantaert T, Rice C, Ravetch J, Bournazos S |
| Journal | Nat Microbiol |
| Volume | 8 |
| Issue | 8 |
| Pagination | 1468-1479 |
| Date Published | 07/10/2023 |
| ISSN | 2058-5276 |
| Keywords | Dengue, Dengue Virus |
| Abstract | Although dengue virus (DENV) infection typically causes asymptomatic disease, DENV-infected patients can experience severe complications. A risk factor for symptomatic disease is pre-existing anti-DENV IgG antibodies. Cellular assays suggested that these antibodies can enhance viral infection of Fcγ receptor (FcγR)-expressing myeloid cells. Recent studies, however, revealed more complex interactions between anti-DENV antibodies and specific FcγRs by demonstrating that modulation of the IgG Fc glycan correlates with disease severity. To investigate the in vivo mechanisms of antibody-mediated dengue pathogenesis, we developed a mouse model for dengue disease that recapitulates the unique complexity of human FcγRs. In in vivo mouse models of dengue disease, we discovered that the pathogenic activity of anti-DENV antibodies is exclusively mediated through engagement of FcγRIIIa on splenic macrophages, resulting in inflammatory sequelae and mortality. These findings highlight the importance of IgG-FcγRIIIa interactions in dengue, with important implications for the design of safer vaccination approaches and effective therapeutic strategies. |
| DOI | 10.1038/s41564-023-01421-y |
| PubMed ID | 37429907 |
| PubMed Central ID | PMC10753935 |