Injectable and Cytocompatible Tough Double-Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking.
| Publication Type | Academic Article |
| Authors | Rodell C, Dusaj N, Highley C, Burdick J |
| Journal | Adv Mater |
| Volume | 28 |
| Issue | 38 |
| Pagination | 8419-8424 |
| Date Published | 08/01/2016 |
| ISSN | 1521-4095 |
| Abstract | Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability. |
| DOI | 10.1002/adma.201602268 |
| PubMed ID | 27479881 |
| PubMed Central ID | PMC7437955 |