A Metabolic Bottleneck for Stem Cell Transformation.
| Publication Type | Comment |
| Authors | Baksh S, Fuchs E |
| Journal | Cell |
| Volume | 182 |
| Issue | 6 |
| Pagination | 1377-1378 |
| Date Published | 09/17/2020 |
| ISSN | 1097-4172 |
| Keywords | Cell Transformation, Neoplastic, Neural Stem Cells |
| Abstract | Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation. |
| DOI | 10.1016/j.cell.2020.08.038 |
| PubMed ID | 32946778 |
| PubMed Central ID | PMC7861329 |