mRNA Export as a Novel Cancer-Specific Dependency.
| Publication Type | Comment |
| Authors | Wang E, Abdel-Wahab O |
| Journal | Cancer Discov |
| Volume | 11 |
| Issue | 9 |
| Pagination | 2129-2131 |
| Date Published | 09/01/2021 |
| ISSN | 2159-8290 |
| Keywords | Neoplasms, Nucleocytoplasmic Transport Proteins |
| Abstract | In this issue, Malone and colleagues identified the nuclear mRNA export factor NXT1 as a novel genetic dependency in neuroblastoma as well as several additional pediatric cancers. These data highlight potential cell type-specific differences in the nuclear export machinery that may be exploited as cancer therapeutics.See related article by Malone et al., p. 2282. |
| DOI | 10.1158/2159-8290.CD-21-0862 |
| PubMed ID | 34479974 |