Neuroinflammation and the cGAS-STING pathway.
| Publication Type | Review |
| Authors | Chin A |
| Journal | J Neurophysiol |
| Volume | 121 |
| Issue | 4 |
| Pagination | 1087-1091 |
| Date Published | 01/23/2019 |
| ISSN | 1522-1598 |
| Keywords | Membrane Proteins, Nervous System Diseases, Nucleotidyltransferases, Signal Transduction |
| Abstract | The recent discovery of cyclic GMP-AMP synthase (cGAS) as the mammalian cytosolic DNA sensor has profound therapeutic implications for infection, immunology, and cancer. Because neurovirology, neuroimmunology, neuro-oncology, and neurodegeneration implicate cytosolic DNA sensing, cGAS activation and induction of the downstream signaling protein stimulator of interferon genes (STING) has become increasingly recognized as a crucial determinant of neuropathophysiology. This Neuro Forum article reviews recent advances on the role of cGAS-STING signaling in neuroinflammation and neurological disease. |
| DOI | 10.1152/jn.00848.2018 |
| PubMed ID | 30673358 |