Oncogenic Mechanisms of Histone H3 Mutations.
| Publication Type | Review |
| Authors | Weinberg D, Allis C, Lu C |
| Journal | Cold Spring Harb Perspect Med |
| Volume | 7 |
| Issue | 1 |
| Date Published | 01/03/2017 |
| ISSN | 2157-1422 |
| Keywords | Chromatin, Glioma, Histone-Lysine N-Methyltransferase, Histones, Mutation, Missense |
| Abstract | Recurrent missense mutations in histone H3 were recently reported in pediatric gliomas and soft tissue tumors. Strikingly, these mutations only affected a minority of the total cellular H3 proteins and occurred at or near lysine residues at positions 27 and 36 on the amino-terminal tail of H3 that are subject to well-characterized posttranslational modifications. Here we review recent progress in elucidating the mechanisms by which these mutations perturb the chromatin landscape in cells through their effects on chromatin-modifying machinery, particularly through inhibition of specific histone lysine methyltransferases. One common feature of histone mutations is their ability to arrest cells in a primitive state refractory to differentiation induction, highlighting the importance of studying these mutations in their proper developmental context. |
| DOI | 10.1101/cshperspect.a026443 |
| PubMed ID | 27864305 |
| PubMed Central ID | PMC5204328 |