Orexin (hypocretin) and addiction.
| Publication Type | Academic Article |
| Authors | Mehr J, Bilotti M, James M |
| Journal | Trends Neurosci |
| Volume | 44 |
| Issue | 11 |
| Pagination | 852-855 |
| Date Published | 10/09/2021 |
| ISSN | 1878-108X |
| Keywords | Neuropeptides |
| Abstract | Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function. |
| DOI | 10.1016/j.tins.2021.09.002 |
| PubMed ID | 34642086 |
| PubMed Central ID | PMC8772282 |