Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues.
| Publication Type | Academic Article |
| Authors | Kadoki M, Patil A, Thaiss C, Brooks D, Pandey S, Deep D, Alvarez D, von Andrian U, Wagers A, Nakai K, Mikkelsen T, Soumillon M, Chevrier N |
| Journal | Cell |
| Volume | 171 |
| Issue | 2 |
| Pagination | 398-413.e21 |
| Date Published | 09/21/2017 |
| ISSN | 1097-4172 |
| Keywords | Immunologic Memory, Interferon Type I, Vaccinia, Vaccinia virus, Viral Vaccines |
| Abstract | A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map of immune processes at the organism level. We uncover two inter-organ mechanisms of protective immunity mediated by soluble and cellular factors. First, analyzing ligand-receptor connectivity across tissues reveals that type I IFNs trigger a whole-body antiviral state, protecting the host within hours after skin vaccination. Second, combining parabiosis, single-cell analyses, and gene knockouts, we uncover a multi-organ web of tissue-resident memory T cells that functionally adapt to their environment to stop viral spread across the organism. These results have implications for manipulating tissue-resident memory T cells through vaccination and open up new lines of inquiry for the analysis of immune responses at the organism level. |
| DOI | 10.1016/j.cell.2017.08.024 |
| PubMed ID | 28942919 |
| PubMed Central ID | PMC7895295 |