Ribosomal profiling of human endogenous retroviruses in healthy tissues.
| Publication Type | Review |
| Authors | Dopkins N, Singh B, Michael S, Zhang P, Marston J, Fei T, Singh M, Feschotte C, Collins N, Bendall M, Nixon D |
| Journal | BMC Genomics |
| Volume | 25 |
| Issue | 1 |
| Pagination | 5 |
| Date Published | 01/02/2024 |
| ISSN | 1471-2164 |
| Keywords | Endogenous Retroviruses, Ribosomes |
| Abstract | Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, while their protein coding capacity remains virtually uncharacterized. Therefore, we applied the bioinformatic pipeline "hervQuant" to high-resolution ribosomal profiling of healthy tissues to provide a comprehensive overview of translationally active HERVs. We find that HERVs account for 0.1-0.4% of all translation in distinct tissue-specific profiles. Collectively, our study further supports claims that HERVs are actively translated throughout healthy tissues to provide sequences of retroviral origin to the human proteome. |
| DOI | 10.1186/s12864-023-09909-x |
| PubMed ID | 38166631 |
| PubMed Central ID | PMC10759522 |