A Siah3 of relief: A role for mitophagy as a fail-safe during developmental axon pruning.
| Publication Type | Academic Article |
| Authors | Davidson R, Simon D |
| Journal | Sci Signal |
| Volume | 17 |
| Issue | 857 |
| Pagination | eads1228 |
| Date Published | 10/08/2024 |
| ISSN | 1937-9145 |
| Keywords | Axons, Mitochondria, Mitophagy, Ubiquitin-Protein Ligases |
| Abstract | Developmental axon pruning is controlled by a careful balance of pro- and anti-apoptotic signals, which are activated in response to external cues to sculpt mature neuronal circuitry. In this issue of Science Signaling, Abraham et al. define a safeguard against apoptotic axon pruning and illustrate that Siah3 represses Parkin-mediated mitophagy to control the availability of axonal mitochondria that activate the pruning process. |
| DOI | 10.1126/scisignal.ads1228 |
| PubMed ID | 39378287 |