Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib.
| Publication Type | Academic Article |
| Authors | Peretz C, McGary L, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis M, Perl A, Huang B, Smith C |
| Journal | Blood Adv |
| Volume | 5 |
| Issue | 5 |
| Pagination | 1437-1441 |
| Date Published | 03/09/2021 |
| ISSN | 2473-9537 |
| Keywords | Benzothiazoles, Phenylurea Compounds |
| Abstract | Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist therapy. |
| DOI | 10.1182/bloodadvances.2020003398 |
| PubMed ID | 33666651 |
| PubMed Central ID | PMC7948271 |