Suppressing Nucleotide Exchange to Inhibit KRAS-Mutant Tumors.
| Publication Type | Comment |
| Authors | Zhao Y, Xue J, Lito P |
| Journal | Cancer Discov |
| Volume | 11 |
| Issue | 1 |
| Pagination | 17-19 |
| Date Published | 01/01/2021 |
| ISSN | 2159-8290 |
| Keywords | Neoplasms, Proto-Oncogene Proteins p21(ras) |
| Abstract | Guanine nucleotide exchange factors (GEF) control the rate-limiting step of physiologic RAS activation. In this issue of Cancer Discovery, Hofmann and colleagues describe the discovery of a selective inhibitor targeting the GEF, SOS1, along with its preclinical effects in suppressing KRAS-mutant tumor growth.See related article by Hofmann et al., p. 142. |
| DOI | 10.1158/2159-8290.CD-20-1331 |
| PubMed ID | 34003780 |