Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.
| Publication Type | Editorial Article |
| Authors | McGary L, Vardhana S |
| Journal | Cancer Discov |
| Volume | 12 |
| Issue | 4 |
| Pagination | 892-894 |
| Date Published | 04/01/2022 |
| ISSN | 2159-8290 |
| Keywords | COVID-19 |
| Abstract | Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8). |
| DOI | 10.1158/2159-8290.CD-22-0080 |
| PubMed ID | 35373282 |